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KMID : 0613819980080040464
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Journal of Life Science
1998 Volume.8 No. 4 p.464 ~ p.471
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Effect of Kamihaengche-tang Plus Yukmijihwang-tang Oxidant-induced Liver Cell injury
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Abstract
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This study was carried out to determine whether Kamihaengche-tang plus Yukmijihwang-tang (KCYH) exerts the protective effect against oxidant-induced liver cell injury. Cell injurt was estimated by measuring lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) release, and lipid peroxidation was estimated by measuring malondialdehyde, a product of lipid peroxidation in rabbit liver slices. H$_{2}$O$_{2}$-increased LDH release which was significantly prevented by 1% KCYHT. The protective effect of KCYH against H$_{2}$O$_{2}$-induced cell injury was dose-dependent in the range of 0.05-1% concentrations. Similary, KCYH inhibited H$_{2}$O$_{2}$-induced lipid peroxidation in a dose-dependent manner. When liver tissuse were exposed to Hg(0.5 mM), ALT activity in the medium and lipid erpoxidation in tissues were markedly increased. These changes were prevented by 1% KCYH. KCHY restored Hg-induced inhibition of cellular GSH content. These result indicate that KCYH exerts the protective effect oxidant-induced liver cell injury, and this effect is attributed to prevented to prevention of lipid peroxidation. These dffects may be due to an increase in concentration of endogenous antioxidants.
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